I have been on Zoloft for a few years now and the only difference I find is that drinking alcohol makes me a little tired and I think I can feel the effect more than I used to (unless its age — I cant keep up like I used to). Also, if you are just starting a new drug, it can take up to 6 weeks until you get the full effects of the drug. Just try a glass of wine, drink it slow and see how your body feels. Everyone's body is different. Otherwise I have no problems having an occasional few. Your body will let you know! I take Zoloft for anxiety, and it works great. What a difference it has made in my life. Good luck!